Breakthrough in the detection of tumor cells with

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Functional nano fluorescent probes have made breakthroughs in the detection of tumor cells

malignant tumor is one of the major diseases that seriously endanger human health. At present, it has become the main cause of human death, and its incidence rate is increasing year by year. If the tumor can be found early and treated in time, the cure rate of the tumor can be greatly improved. Therefore, the early detection and diagnosis and treatment of tumors have become a hot spot for scientists all over the world in the fields of thermoelectric conversion materials and solar cells. In order to achieve early diagnosis and treatment of tumors, most of the current research focuses on the detection of a tumor marker in living cells, which may lead to "false positive" results. Because some tumor markers are expressed not only in cancer cells, but also in normal cells, it is of great significance to detect the expression of multiple tumor markers in living cells at the same time. So far, the simultaneous detection and imaging of three or more tumor markers in living cells have not been achieved in the world

with the strong support of the National Natural Science Foundation of China, the research group of Professor Tang Bo from the school of chemistry, chemical engineering and materials science of Shandong Normal University and the Key Laboratory of molecular and nano probes of the Ministry of education has made important progress in tumor cell detection and imaging. The relevant research results have been published in the recent German Journal of Applied Chemistry as an internal cover article (angew. chem. int. edit. 2012, 51,)

based on gold nanoparticles, the research group designed a multicolor nano fluorescent probe to realize the simultaneous detection and imaging of three tumor markers in living cells. The probe has been successfully used to distinguish breast cancer cells, liver cancer cells and normal breast cells and liver cells, and can be used in polypropylene, polyamide and engineering thermoplastic polyurethane polymers to evaluate the different expression levels of tumor markers in cells. Compared with the traditional single marker detection, this method can effectively avoid the possible "false positive" results, so as to improve the reliability of early cancer diagnosis

in recent years, Professor Tang Bo's research group has carried out systematic research on the design, preparation and application of functional nano fluorescent probes for tumor cell detection, imaging and treatment, and achieved outstanding results (biomaterials. 2012, 33,; chem. EUR. J., 2012, 18,; chem. EUR. J., mainly steel 2011, 17, 11210 -11215; chem. commun., 2011, 47,; chem. commun., 2011, 47,)

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